Grey’s Anatomy has been going for almost two decades. The 21 seasons and nearly 450 episodes have introduced viewers to plenty of characters, but few have been as popular with fans as Dr. Derek Shepherd, who’s been affectionately referred to as “McDreamy.” Derek is a neurosurgeon who works at the same hospital as the main character, Meredith Grey, and even had a relationship and kids with her. Patrick Dempsey won over audiences’ hearts as Derek Shepherd, and even received the honor of People Magazine’s “Sexiest Man Alive” in 2023 after showing so much charisma in Grey’s Anatomy.