Mayfair Witches is a supernatural drama based on Anne Rice‘s novel trilogy, Lives of the Mayfair Witches. The plot revolves around a neurosurgeon, Dr. Rowan Fielding, who learns she is the heiress to the powerful Mayfair dynasty of witches. Meanwhile, Ciprien Grieve, an empath and Talamasca agent, is assigned to her, vowing to protect her even before meeting her.